Due of its influence on tumour behaviour, the tumour microenvironment and its components have garnered interest recently. This microenvironment is dominated by M2 macrophages. This study examined the percentage of M2 macrophage expression in head and neck squamous cell carcinoma at the primary tumour location, regardless of grade. This connection was further examined utilising CD163 immunohistochemical labelling at the primary tumour and associated lymph node metastases. A total of 20 squamous c