* Researchers at University Hospitals, Case Western Reserve University and the Cleveland VA identified a key molecular driver of age-related cognitive decline, offering a potential path toward the development of new treatments. * Published today in PNAS, the study pinpoints a key protein behind age-related breakdown of the blood-brain barrier (BBB), which leads to cognitive decline. * The research team showed that loss of a protein called KLF4 in blood vessel cells weakens the BBB and accelerate