Clinical and Public Health Irrelevance of Null Findings: The Critical Substrate Role of Calcium and Vitamin D

Agreement: I Agree Body: Dear Editor, Massé and colleagues’ systematic review and meta-analysis of 69 randomized controlled trials provides a comprehensive overview of calcium and vitamin D supplementation [1]. However, several methodological constraints require careful consideration before these findings are translated into clinical guidelines or public health policies. First, the composition of the analyzed cohort introduces a substantial selection bias regarding baseline risk. Community-dwel