Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and is increasingly diagnosed in the Middle East, including Kuwait. To characterize its genomic landscape, targeted next-generation sequencing was performed on 72 histologically confirmed PTC tumors collected between 2019 and 2022. DNA from FFPE samples was analyzed using a high-depth cancer gene panel with standardized pipelines for variant calling, annotation, and pathogenicity filtering. The cohort (median age 46.5 years)