Researchers build FEDE brain twin recreating toddler brain activity

Researchers developed FEDE (high FidElity Digital brain modEl), a computational pipeline that combines three MRI modalities with finite-element biophysical simulation to build patient-specific virtual brain models. Published in PLOS Digital Health, the study demonstrated the approach by constructing what the authors describe as the first brain digital twin of a toddler (age 2.4) with autism spectrum disorder (ASD). The model closely replicated EEG recordings of the child's brain activity and est