health
Urine cell-free RNA for bladder cancer detection and treatment response prediction
Urine biomarkers promise to improve noninvasive detection and molecular characterization of genitourinary malignancies. Here we describe urine random priming and affinity capture of cell-free RNA (cfRNA) fragments for enrichment analysis by sequencing (uRARE-seq), a liquid biopsy method for urine cfRNA profiling, and apply it to 683 urine samples from patients with cancer and controls. Urine cfRNA contained transcripts from genitourinary tissues and, in patients with prostate, kidney or bladder
Analysis of urine cfRNA
In contrast to RNA from cellular urinary sediments, cfRNA from urinary supernatants is highly fragmented (Extended Data Fig. 1a), suggesting that a sequencing approach optimized for short RNA fragments would be required. We th... [47793 chars]
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